Social Isolation May Change In The Brain, Increase Stress, Aggression, And Fear:
Social isolation has been a growing problem in modern society and not only has increased rates of depression and post-traumatic stress disorder, but also due to the high risk of chronic disease.
For two weeks, different rats showed behavioral changes such as strangers, constant fear, and increasing aggression towards susceptibility to threatening stimuli.
When facing a dangerous stimulation, after the passage of blood, the socially isolated rats remain frozen in the place, whereas immediately after the expiration, the normal mice stop cooling.
Although the study is doing in rats, but in the United States, California's Institute of Technology's postdoctoral scholar Lead author Morial Zelikovsky said that the study has a potential to understand how chronic stress affects humans and mental health disorders There are potential applications for treatment.
Previous studies have determined that social isolation for two weeks in mice, which is an upgrade of signaling molecule neuropeptide, tachicinin 2 (TAC 2) / neurokinin B (NKB), which is a small protein molecule.
In the new study, publication in the journal Cell, the team found that the old isolation TAC 2 leads to an increase in expression of gene and the production of a neuropeptide is called neurokinin B (nkb) in your brain.
However, the administration of a drug which is a chemical block NKB-specific receptors that enables stressed mice to behave in general, eliminates the harmful effects of social isolation.
On the other hand, by artificially increasing the levels of TAC 2 and generally activating this neurons, the animals led them to behave differently and like stress, the research revealed.
Researchers say that according to the pressure of TAC 2 genes in some different brain parts, fear behaviors, or aggression, it shows that it should move to create different effects of social isolation in different brain regions.
So, they show that the description of social isolation can change in the brain, stress, aggression and fear can increase.
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